To examine this effect, as well as the association of LV longitudinal myocardial function with LV diastolic function after administration of SGLT2 inhibitor in T2DM patients with stable HF, we analyzed data from a previous prospective multicenter study of ours, in which we investigated the effect of SGLT2 inhibitor on LV diastolic functional parameters including E/e′ and left atrial volume index (LAVI) of T2DM patients with stable HF at five institutions in Japan [13]. The gene discussed is SLC5A2; the disease is hydrops fetalis.