Large clinical trials using other SGLT2 inhibitors such as empagliflozin (EMPA-REG OUTCOME trial) [23] and canagliflozin (CANVAS Program) [24] also found that T2DM patients at high risk of cardiovascular events derived cardiovascular benefits from the SGLT2 inhibitor as compared to a placebo. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.