Additional investigations will include changes in dietary intake and physical activity, changes in the biochemical profile of the pregnant women (fasting glucose, fasting insulin, total cholesterol, cholesterol fractions, triglycerides and C-reactive protein), pregnancy complications (GDM, hypertensive disorders and prematurity), birth weight, and weight and length/height of the children at 6, 12 and 24 months of age. The gene discussed is INS; the disease is hypertensive disorder.