If the pressure sensitivity of natural PSDs are similar or even higher than that of the SynGAP/PSD‐95 droplets, our findings may help decipher the underlying mechanisms of neurological disorders of vertebrates under pressures that are not much higher than atmospheric pressure at sea level,33 including onset of high‐pressure neurological syndrome at approximately 10 bar.29 Here, SYNGAP1 is linked to nervous system disorder.