To further reveal the genetic mechanism behind inguinal hernia, the DBFS algorithm was used to detect a series of common downstream proteins that directly interacted with inguinal hernia-causative proteins, in which UBC, GRB2, CTNNB1, HSP90AA1, PLCG1, CBL, and CRK are listed as the top seven downstream common proteins. This evidence concerns the gene GRB2 and Inguinal hernia.