PIK3R1, PTPN11, SOS1, TGFBR1, TGFBR2, CDC42, KRAS, HRAS, RET, and PDGFRA were listed as the top ten proteins based on the overlapping cluster number of hernia-causative genes, in which PIK3R1 and PTPN11 were significantly involved in the inguinal hernia PPI network. This evidence concerns the gene PTPN11 and Inguinal hernia.