Luciferase activity reporter assay revealed the direct interaction of MIR‐142‐5p and KCNQ1OT1. Moreover, by exploring the target of MIR‐142‐5p, we identified a direct connection of MIR‐142‐5p and CAPN10. CAPN10 was found highly expressed in OC cells and predicted poor overall survival of cancer patients. Here, CAPN10 is linked to cancer.