We have also started to understand that at different stages of certain tumors SWI/SNF complexes can act either as tumor suppressors or as oncogenes.11, 12, 13 These mechanistic insights are providing new therapeutic opportunities, and targeting SWI/SNF subunits has great potential for the development of novel cancer therapies,2, 3, 4, 5, 14, 15 and several efforts are ongoing to develop BRG1 inhibitors.9 The gene discussed is SMARCA4; the disease is cancer.