SMARCA1 and neoplasm: We have also started to understand that at different stages of certain tumors SWI/SNF complexes can act either as tumor suppressors or as oncogenes.11, 12, 13 These mechanistic insights are providing new therapeutic opportunities, and targeting SWI/SNF subunits has great potential for the development of novel cancer therapies,2, 3, 4, 5, 14, 15 and several efforts are ongoing to develop BRG1 inhibitors.9