TP53 and amyotrophic lateral sclerosis: Xrp1 had previously been implicated in the DNA damage response downstream of p53 and in the transposition of P elements, and contributes to the pathology of a Drosophila model of Amyotrophic Lateral Sclerosis, as well as to the coordination of organ growth in flies with Rp gene knockdowns (Brodsky et al., 2004; Akdemir et al., 2007; Francis et al., 2016; Mallik et al., 2018; Boulan et al., 2019).