Although there was no report regarding the relationship between MDM‐2 genetic polymorphisms and ND or functional outcome after IS, some studies have shown that MDM‐2 polymorphisms may be a risk factor for uterine fibroids and hepatocellular carcinoma (Dong et al., 2012; Salimi et al., 2015). The gene discussed is MDM2; the disease is hepatocellular carcinoma.