Most prominently we observed OCA to reduce a number of inflammatory markers in the NASH model, corroborating the results by other preclinical studies18, 19, 46 and those from phase II clinical trials.33 Interestingly we observed a significant decrease in IL‐6 production, but only a minimal effect on gene expression, suggesting that OCA affects the translation, posttranslational modification, or secretion of this cytokine. The gene discussed is IL6; the disease is metabolic dysfunction-associated steatohepatitis.