PNPLA3 and metabolic dysfunction-associated steatohepatitis: The I148M SNP in the PNPLA3 gene is highly associated with an increased risk of developing hepatic steatosis, NASH, and liver fibrosis.3, 25 Recently, a role for the mutated protein has been revealed in HSCs, where it has been shown to cause these cells to increase their activation status, become more pro‐inflammatory, and have a higher lipid content.35 By taking HSC donors that contained the WT or mutant I148M PNPLA3 allele, we were able to confirm these findings using our in vitro MPS NASH model.