To explore more broadly the effects of OCA dosing, we analyzed the expression of a range of NASH‐associated genes and found that OCA significantly reduced the expression of genes associated with inflammation (e.g., interferon‐inducible protein 10 [IP‐10], monocyte chemoattractant protein 1 [MCP1], TNF‐α) and a small number associated with fibrosis (e.g., TGFβ, ACTA2) (Fig. 3B,C). Here, ACTA2 is linked to metabolic dysfunction-associated steatohepatitis.