The rise time of the contraction was unaltered between the groups (control, 20.6 ± 0.5 ms; CF monolayer, 17.9 ± 0.9 ms; IL-1β CF monolayer, 20.4 ± 0.7 ms; Figure 6B), while the CD50 was significantly reduced in CMs in co-culture with an untreated CF monolayer (Figure 6C) (36.1 ± 1.1 ms vs. 47.3 ± 2.4 ms; CF monolayer vs. control; P < 0.05). This evidence concerns the gene IL1B and cystic fibrosis.