In scurfy mice, a mouse model of human IPEX syndrome, treatment with TGFβ-differentiated FOXP3+ T cells from wt mice or autologous transplantation of hematopoietic stem cell containing a lentiviral vector for FOXP3 overexpression has been shown to sufficiently prevent skin inflammation14,15. This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.