TP53 and cancer: The tumor suppressor protein, p53, is a transcription factor that controls both activation and repression of gene expression in eukaryotic cells.33,34 Wild-type p53 (WT p53) regulates the expression of many genes by inducing or repressing transcription, whereas loss or mutation of p53 promotes tumorigenesis.33–35 Inactivation of WT p53 is a common event during cancer development and nearly half of all human cancers, and over 80% of TNBC patients, harbor mutations in the p53 gene, resulting in loss of WT p53 activity.36