High expression of E2F1A is associated with poor prognosis and controls cell cycle, apoptosis, autophagy, differentiation, and stress response in many cancer types.76–79 Thus, the results by us and by others demonstrate that the transcriptions factors that control MELK expression, E2F1A, FOXM1, and p53, also regulate key biologic functions of cancer cells. Here, MELK is linked to cancer.