TP53 and breast carcinoma: We analyzed breast cancer data sets (Curtis and TCGA) to determine whether MELK expression correlates with WT p53-induced or repressed genes.45 Analysis of breast cancer data sets revealed that MELK expression is significantly correlated with p53-repressed genes (Fig. 3f and Supplementary Fig. 3C) but not with p53-induced genes (Supplementary Fig. 3D).