The elevation of MELK expression is also observed in multiple human cancers where p53 is commonly mutated, suggesting that high expression of MELK in p53-mutant tumors is not specific to breast cancer and is a common phenomenon in multiple human cancer types.3,14,15,18,24,55,67,68 Thus, our results in TNBCs may also be relevant for other cancer types. This evidence concerns the gene TP53 and breast cancer.