In our previous studies, we identified several kinases overexpressed in TNBCs as compared with ER-positive breast cancers and showed that inhibition of the expression of several of these kinases suppressed the growth of TNBC cells.1 One such critical kinase is the maternal embryonic leucine zipper kinase (MELK).1 Several reports have identified that MELK expression is highly elevated in many human cancers and high MELK expression is associated with poor prognosis.2–7. The gene discussed is MELK; the disease is cancer.