To investigate the mechanism by which MELK expression is highly elevated in TNBCs, we analyzed The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) breast cancer patient data sets (cBioPortal) to determine whether upregulated MELK expression correlates with gene copy number, promoter methylation, or any specific oncogenic mutations. The gene discussed is MELK; the disease is cancer.