If only the interventions for CVD with the lowest ICERs, within the CVD category, were scaled-up by 20% in Ethiopia (primary prevention of CVD for individuals with >35% risk of CVD; ASA, streptokinase and ACE-inhibitor for treatment of acute myocardial infarction; ASA, beta-blocker, statin and ACE-inhibitor as secondary prevention after myocardial infarction and ASA, statin and ACE-inhibitor as secondary prevention after stroke), total annual health benefit is expected to be 122 600 DALYs averted and budget impact is estimated to be around US$21.3 million (US$0.20 per capita). The gene discussed is ACE; the disease is acute myocardial infarction.