39 This antigen is a well-known immunogen and vaccine candidate40,41 that is able to induce multifunctional CD4+ T cells in HIV and non-HIV co-infected TB patients.42 It induces a subset of CD4+ T cells with cytolytic functions,41 and it is a known adhesin43 that is involved in bacterial agglutination and has been implicated in the dissemination of M.tb. This evidence concerns the gene CD4 and tuberculosis.