GOT1 and colorectal carcinoma: However, given that the steady state profiling data for the unperturbed cells were largely similar (Additional file 1: Figures S3 and Figure S4), we then examined how the metabolome of GOT1 dependent and independent lines responded to knockdown using three PDA and three CRC iDox-shGOT1 cell lines (Additional file 2: Extended Table 1).