GOT1 and Patent ductus arteriosus: We also found that several nodes in nucleotide metabolism were deregulated in PDA cells upon GOT1 inhibition by modeling our metabolomics data with the Recon1 genome-scale network model [26, 27] with dynamic flux analysis (DFA) [28, 29] (Additional file 1: Figure S7c,d, Additional file 3: Extended Table 2).