Secondly, our study showed that the recently approved cephalosporin-beta-lactamase inhibitor combinations targeting infections with resistant Gram-negative bacteria: ceftolozane-tazobactam and ceftazidime-avibactam, that received marketing authorization valid throughout the European Union in 2015 and 2016, respectively [17, 18], were not always available in ICUs in EU/EEA countries. This evidence concerns the gene LACTB and infection.