The increasing trend of IL-6 and Il-1β can be explained by antipsychotics (especially atypical antipsychotics) side effects such as metabolic syndrome in the long period (93), as increased levels of IL-6, IL-1β, TNF-α, IL-2, IFN-γ, and IL-4 have been reported in patients with metabolic syndrome (94, 95). Here, TNF is linked to metabolic syndrome.