IDH2 and neoplasm: Analysis of the genetic mutations of IDH indicated that 10 cases of the examined genetic mutations through generated or recurrent xenografts precisely replicated in the corresponding xenograft tumors, with the exception of case 20180521, revealed a low heterozygous G/A (11.7%) mutation in the original patient tumor that altered to a GG genotype in the xenografts through serial generations and distant aggressive tumors (Fig. 7).