The results of the present study showed that NLR could be a reliable tool or adjunct in diagnosing acute appendicitis since it has good sensitivity and specificity compared to other parameters such as TWBC (sensitivity: 62%, specificity: 75%), CRP (sensitivity: 57%, specificity: 87%), mean platelet volume (sensitivity: 59%, specificity: 59.5%) and pro-calcitonin (sensitivity: 33%, specificity: 89%) (22, 32). This evidence concerns the gene CRP and appendicitis.