High E33 expression was remarkably correlated with TNM stage (P = .002), lymph node metastasis (P = .015), and family history (P = .013), but not correlated with patient's age and tumor grade, as well as ER, PR, and Her2 status (P > .05). This evidence concerns the gene NDUFAF3 and metastatic malignant neoplasm in the lymph nodes.