High E33 expression was remarkably correlated with TNM stage (P = .002), lymph node metastasis (P = .015), and family history (P = .013), but not correlated with patient's age and tumor grade, as well as ER, PR, and Her2 status (P > .05). The gene discussed is ERBB2; the disease is metastatic malignant neoplasm in the lymph nodes.