TREM2 has been shown to be important for phagocytosis, a crucial function of microglia that is found to be aberrant in neurodegenerative diseases such as Alzheimer’s.6, 30 We have shown previously that NHD‐associated TREM2 variant iPS‐Mg have a deficit in phagocytosis of apoptotic cells31; however, this is not observed in R47H (data not shown). Here, TREM2 is linked to neurodegenerative disease.