GPT and Hyponatremia: Regarding grade 3/4 biochemical abnormalities, bilirubin (10%), aspartate aminotransferase (20%), alanine aminotransferase (10%), hypertriglyceridemia (10%), hyponatremia (10%), and hyperglycemia (10%) were observed at the 2.0 mg/kg dose level, and bilirubin (33%) was observed at the 4.0 mg/kg dose level.