An interesting finding in this study was the detection of critical pathways and functions such as EGF, Wnt, MAPK, HIF, P53, CFTR, AMPK, PDGF, NFκB, IGF1, MET signaling, oxidative phosphorylation, energy metabolism, cell–cell and cell–matrix interaction, and signaling by interleukins which were previously shown to be associated with ADPKD in experimental studies [19–21], and other pathways could consider for more studies and validation. Here, TP53 is linked to autosomal dominant polycystic kidney disease.