An interesting finding in this study was the detection of critical pathways and functions such as EGF, Wnt, MAPK, HIF, P53, CFTR, AMPK, PDGF, NFκB, IGF1, MET signaling, oxidative phosphorylation, energy metabolism, cell–cell and cell–matrix interaction, and signaling by interleukins which were previously shown to be associated with ADPKD in experimental studies [19–21], and other pathways could consider for more studies and validation. The gene discussed is EGF; the disease is autosomal dominant polycystic kidney disease.