In addition, LINC00665 and miR-379-5p were significantly enriched in AGO-containing microribonucleoprotein complexes by RNA immunoprecipitation (RIP) assay, suggesting that both LINC00665 and miR-379-5p bind directly to AGO2 in breast cancer cells (Fig. 4e). The gene discussed is FBXW7; the disease is breast cancer.