Nonetheless, immunohistochemistry, immunoblots and qRT-PCR indicated that IL-24 expression was reduced in patients with liver cirrhosis and even lower in those with ALF (Figs. 6a–c, f and 7), whereas CHOP expression was concomitantly escalated in cirrhosis and ALF patients (Fig. 6a, f), suggestive of a strong correlation between IL-24 expression and hepatocyte stress. Here, DDIT3 is linked to cirrhosis of liver.