We found a trend for interactions between APOE-ε4 status and insomnia in WAIS-IV Matrix Reasoning test (p = 0.042 in the additive model), in WAIS-IV Digit Span test (p = 0.036 in the dominant model), and in MBT-TDFR (p = 0.034 in the recessive model), but none of them survived correction for multiple comparisons. The gene discussed is APOE; the disease is insomnia.