SCN2A and Encephalopathy: Therefore, following these statements we can talk about “SCN2A encephalopathy” only in the case of an early-onset infantile epileptic encephalopathy but not in the case of benign familial neonatal-infantile seizures or generalized epilepsy febrile seizures plus, and similarly we can talk about “KCNQ2 encephalopathy” only in the case of an early-onset epileptic encephalopathy with suppression burst or a late-onset epileptic encephalopathy with continuous spikes and waves during slow-wave sleep syndrome, but not in the case of benign familial neonatal seizures.