In recent years, several studies including ours have revealed that G-CSF as an endogenous growth factor and immune system modulator factor [46] is beneficial in models of neurological disorders such as stroke and traumatic brain injury [23, 47] Although the anti-apoptotic activity of G-CSF is reported in global cerebral ischemia, this mechanism is still not fully explored. The gene discussed is CSF3; the disease is stroke disorder.