Furthermore, to confirm the correlation between miR-381, YAP, and Snail and human lung cancer metastasis in vivo, we established A549 lines stably overexpressing miR-381 inhibitors (miR-381 inh + shNC), co-overexpressing miR-381 inhibitors and shYAP (miR-381 inh + shYAP), and control cells (control+shNC). Here, SNAI1 is linked to lung cancer.