In favor of this speculation, we observed chitotriosidase activity differently expressed in patients with severe pulmonary involvement (presence of lung fibrosis at CT scan), with multi vs. single organ involvement (in particularly in patients with abdominal involvement and with three or more extrapulmonary localizations), with active vs. non-active disease and with remitted/minimal vs. persistent disease and in patients at high clinical risk (expressed by CPI index). The gene discussed is CHIT1; the disease is pulmonary fibrosis.