CHIT1 and lung disorder: According GenPhenResA phenotypes [16], patients with abdominal organ involvement had higher chitotriosidase activity than other groups (q=8.155, p<0.0001 vs ocular-cardiac-cutaneous-central-nervous-system; q=11.32, p<0.0001 vs musculoskeletal-cutaneous; q=14.97, p<0.0001 vs isolated pulmonary disease; q=11.49, p<0.0001 vs extrapulmonary disease), while ocular–cardiac–cutaneous–central-nervous-system (OCCC) localization showed higher chitotriosidase activity than isolated pulmonary involvement (q=4.494; p<0.05) (Fig. 4).