In line with this observation, Harlander et al. reported a significant increase in chitotriosidase activity during relapse of sarcoidosis [13]. Unfortunately, due to retrospective nature of this study, we could not explore chitotriosidase in relation with quality of life as standardized specific questionnaires were not available for the majority of patients included in the study. The gene discussed is CHIT1; the disease is sarcoidosis.