Within the cohort of HD, while 7OD raised the frequency of CD4+ T-bet+ cells, DHEA expanded the CD4 + FoxP3 + RORγ-t + population and declined the number of cells that co-expressed FoxP3+ and T-bet after antigen (Ag)-exposure (Additional file 3: Figure 3A). The gene discussed is FOXP3; the disease is Huntington disease.