Unlike the one-time Ad-CYP2D6 (CYP2D6 gene incorporated into adenovirus) infection determined by Christen et al., in the present study, we established, for the first time, a mouse model to mimic constantly the pathological process of AIH in vivo by combining the initial one-time adenovirus infection and repeated injections of human CYP2D6 plasmid. This evidence concerns the gene CYP2D6 and infection.