METTL3 and obesity due to melanocortin 4 receptor deficiency: m6A modification was reported to be involved in the DNA damage response following ultraviolet irradiation, which is regulated by the methyltransferase METTL3 (methyltransferase-like 3) and the demethylase FTO (fat mass and obesity-associated protein), suggesting m6A might be a promising target for combined therapy with radiotherapy or chemotherapy [20].