Additionally, we found frequent deletion and downregulated expression of ALKBH5 in 2 Gene Expression Omnibus (GEO) datasets (GSE16515 and 106,901) of PDACs compared to their matched normal tissues (NT), which was also validated by qRT-PCR analysis of matched tumor and adjacent tissues (Additional file 2: Figure S2a and Fig. 1e-g). Here, ALKBH5 is linked to neoplasm.