In terms of PDAC, ALKBH5 expression was remarkably downregulated in cancer tissues compared with adjacent normal tissues as determined by immunohistochemistry assay, which was also correlated with certain clinicopathological features like TNM staging, tumor size, lymph node metastasis, and distant metastasis (Additional file 2: Figure S2h and Additional file 12: Table S1). The gene discussed is ALKBH5; the disease is cancer.