HIF1A and hepatocellular carcinoma: There were some studies on inhibiting apoptosis and promoting cell growth, for example, transcriptional co-activators with PDZ-binding motif (TAZ) can promote cell growth and inhibits Celastrol-induced cell apoptosis [42], HSP90 (Heat Shock Protein 90) can inhibit apoptosis and promote growth by regulating HIF-1α (Hypoxia Inducible Factor-1α) abundance in hepatocellular carcinoma [43].