On the other hand, in vitro data showed Orai1 upregulation after hypertrophic stress and demonstrated that Orai1 silencing is associated with protection from hypertrophy via reduced calcineurin (CaN) activity.4,11 Likewise, it has been recently reported that in vivo overexpression of SOCE-associated regulatory factor in the heart prevents cardiac hypertrophy probably through suppressing the upregulation of STIM1 and Orai1.12 The gene discussed is STIM1; the disease is cardiac hypertrophy.