Normal intestinal crypt-based columnar (CBC) stem cell markers, including leucine rich repeat containing G protein-coupled receptor 5 (LGR5) and EPH receptor B2 (EPHB2), have been shown to be over-expressed in colorectal adenocarcinomas, and colorectal tumours that display a stem cell signature correlate with a decrease in disease-free survival of patients and an increase in relapse [15,16]. The gene discussed is EPHB2; the disease is colorectal neoplasm.