In a recent study, the same group also demonstrated that MAP4K4 promoted the epithelial-mesenchymal transition and invasiveness of HCC cells largely via activation of the c-Jun N-terminal kinase(JNK) and the nuclear factor ‘‘kappa-light-chain-enhancer’’ of activated B-cells (NF-κB) signaling [143]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.