As siRNA mediated knockdown of XPO5 leads to reduced levels of plenty of the cellular miRNAs in melanoma [272], it is reasonable to assume that elevated XPO5 protein levels as seen in melanoma are responsible for the general elevation of miRNA levels which is a quite exclusive feature in melanoma (see section “the role of miRNAs in melanoma and hepatocellular carcinoma”). Here, XPO5 is linked to hepatocellular carcinoma.