BCL2 and hepatocellular carcinoma: In this respect, we showed that deltarasin—a novel small-molecule KRAS inhibitor—strongly inhibited proliferation and induced apoptosis in HCC and in melanoma cells, which was associated with the inhibition of the downstream RAF/MAPK- and PI3K/AKT pathway as well as with the down-regulation of anti-apoptotic (BCL-2, BCL-XL) and the up-regulation of pro-apoptotic (BAX, PUMA) molecules [109] (Figure 3).