In addition, the activation of NF-κB, for example, via the Staphylococcal nuclease domain-containing 1 (SND1), which is upregulated in HCC, induces expression of miR-221 and leads to subsequent activation of the pro-angiogenic factors angiogenin and CXCL16 [267]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.