XPC and xeroderma pigmentosum group A: In 2013 Dupuy et al. [47] used engineered MN and TALE nuclease to promote the targeted correction of XPC mutation in the XP4PA cell line, derived from fibroblasts of a Xeroderma pigmentosum group C (XP-C) patient, which carries the homozygous autosomal recessive DTG mutation in the XPC gene.