Intriguingly, more extensive characterizations of intestinal CD4+ T-cells revealed cells with mixed IFN-γ and IL-17 profiles (here denoted as IL-17+IFN-γ+ CD4+ T-cells; also named Th1/Th17 cells or Th17.1 cells) in IBD patients but not healthy individuals [161,178,179]. This evidence concerns the gene CD4 and inflammatory bowel disease.