In keeping with murine colitis studies showing that IL-23 promotes inflammation through induction IFN-γ expression in Th17 cells, these MDR+ IL-17+IFN-γ+CD4+ T-cells (CCR6+CXCR3hiCCR4loCCR10negCD161+) cells had an inflammatory profile and in addition displayed resistance to glucocorticoids in vitro [180,183]. The gene discussed is IL23A; the disease is colitis.