F5 and androgen insensitivity syndrome: On the other hand, in a large cohort of almost 900 pediatric patients with first-ever AIS from Canada, the UK, and Germany, a subsequent AIS event was diagnosed in almost 18% of patients and the authors found that the presence of isolated mutations in FV at rs6025, as well as in FII at rs1799963, were not individually significantly associated with recurrent AIS [29].