Focusing on Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1), a deubiquitinating enzyme that has a putative oncogenic role in various cancer types [13,14,15,16,17,18], we sought to elucidate the molecular mechanism by which UCHL1 promotes tumor progression in USC, and evaluated the effect of targeting UCHL1 on tumor cell proliferation in vivo. Here, UCHL1 is linked to cancer.