GSK3B and melanoma: We also found that fisetin significantly increased intracellular β-catenin expression in B16F10 cells and that the inhibition of β-catenin, suppressed fisetin-mediated melanogenesis in B16F10 melanoma cells and zebrafish larva, which showed that fisetin influences melanogenesis through the activation of β-catenin via the inhibition of GSK-3β.