Conversely, Western blot results demonstrated increased levels of mito-fission related Fis1 in adipose tissue of control HFD-fed mice (Figure 3) an effect of obesity that was completely prevented in adipose tissue of the Lnv-adipo-HO-1 mice fed an HFD (Figure 3). The gene discussed is FIS1; the disease is obesity due to melanocortin 4 receptor deficiency.