Unsupervised clustering confirmed the target genes (LOX, p16, α-SMA, COL1A1, and FAP) upregulation in thyroid cancers and in particular in those with BRAF-like signaling (115 out of 206 BRAF-like tumors clustered in the 5-genes overexpressing group; p-value < 0.0001) (Figure 6B). The gene discussed is ACTA1; the disease is thyroid cancer.