Meanwhile, alterations involving RAS or other genes (PAX8/PPARG, specific gene fusions and PI3K pathway effectors) that display RAS-like signaling are more frequently detected in TCs of follicular origin (FTC and PDTC/ATC that derive from FTC) that display more frequent spreading via blood vessels and distance metastases. Here, PAX8 is linked to thyroid cancer, nonmedullary, 2.