The analyses on human thyroid cancer tissues presented in this work provide lines of evidence that not only confirm previous reports about the involvement of cancer-associated fibroblasts and senescent TC cells in BRAFV600E-expressing PTC, but also provide a revised and improved model of thyroid cancer invasion in which these two cell types may possibly cooperate to promote the invasiveness of other thyroid cancers driven by BRAF-associated oncogenic events. The gene discussed is BRAF; the disease is thyroid cancer.