GLIS2 and breast cancer: One example is the lncRNA Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) that influences cell migration in breast cancer by binding to Smad Nuclear Interacting Protein 1 (SNIP1) and Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PNUTS), two transcription factors that induce the activation of a non-canonical hedgehog/GLI2 (GLI Family Zinc Finger 2) transcriptional program [92].