S1P2, however, appears to have a negative effect on GBM cell migration, although these findings did not extend to invasiveness, as the overexpression of S1P2 in U-118 MG GBM cells in vitro was able to induce the expression of proteins which interact with extracellular matrix components to promote GBM cell invasion [209]. Here, S1PR2 is linked to glioblastoma.