Co-treatment of these chemo-resistant GBM cells with small molecule GCS inhibitors D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), and DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) or N-(n-nonyl)deoxygalactonojirimycin (N-DGJ) with either TMZ or Paclitaxel, increased cell death, suggesting GCS inhibition sensitizes cells to chemotherapy [137]. This evidence concerns the gene UGCG and glioblastoma.