SIK3 and cancer: At final it is interesting to note that a group of proteins: apolipoprotein A-I (Aap-A1), kinectin (Ktn-1), myosin-9 (Myo-9), spectrin alpha chain (Spec a) and serine/threonine-protein kinase SIK3 (SIK-3) show increased carbonylation levels in PL areas compared to both NPE and L regions suggesting their oxidation characterize the NPE/PL transition while their structural rescue favours the adaptive mechanism observed in cancer.