In the context of CRC, Rubio-Patiño and colleagues showed in different mouse cancers models of CRC that mice fed a low-protein diet prompted the induction of IRE1α and RIG1 signaling downstream of ERS, resulting in increased levels of cytokines, effective assembly of the immune response, and reduced colorectal tumor growth [146]. The gene discussed is ERN1; the disease is colorectal carcinoma.