In the absence of unsafe or detrimental effects, long-term CER reduced basal metabolic rate and metabolic syndrome score, and improved multiple systemic markers for cardiometabolic health, including reduced LDL-cholesterol, total cholesterol to HDL-cholesterol ratio, systolic and diastolic blood pressure, C-reactive protein, leptin, fasting insulin, insulin sensitivity index, thyroid hormones T3 and T4, nighttime core body temperature, and markers of oxidative damage (urinary F2-isoprostane); and increased adiponectin levels [28,29]. Here, INS is linked to metabolic syndrome.