TP53 and uterine corpus sarcoma: This could be verified in our own model of the apoptosis-resistant uterine sarcoma cell line ESS-1; in contrast to suberoylanilide hydroxamic acid (SAHA)-inducible apoptotic cell death in the cell line MES-SA, ESS-1 was found to undergo autophagy-associated cell death due to a homozygous nonsense mutation in the TP53 gene that causes p53 protein deficiency or degradation [49,50].