TP53 and uterine corpus sarcoma: Also in our previously described model of the uterine sarcoma cell line ESS-1, the activation of SAHA-induced autophagy could be explained by elimination of mutant p53 (mutp53-R213X) and the lack of p53 protein; although not yet experimentally verified, which could target the cytoplasmic p53-mediated negative regulatory pathway of autophagy [49].