Increased acetylation of the p53 protein following specific inhibition of class III NAD-dependent deacetylases SIRT1 and SIRT2 by sirtinol or combined sirtinol/MHY2256 treatment, preventing MDM2-mediated degradation, yielded elevated LC3-II expression and autophagy, in addition to cell cycle arrest and apoptosis in MCF-7 breast cancer cells or in endometrial cancer cells, respectively [131,132,133]. Here, TP53 is linked to breast cancer.