HDACi-dependent autophagic induction involving p53 was previously reported by our own study, that revealed p53 deficiency as the cause of mTOR signaling-mediated autophagy in SAHA-treated ESS-1 uterine sarcoma cells, and in MDA-MB-231 breast cancer cells by Fogetti et al. [49,122,123,237,259]. This evidence concerns the gene TP53 and breast cancer.