In a recent study, Rahamati et al. [57] showed that in secretory endometrium of implantation failure patients there was a decrease in G-CSFR mRNA expression with respect to recurrent miscarriage cases and controls, and when the endometrial biopsy were “in vitro” cultured with G-CSF the mRNA of G-CSFR increased. The gene discussed is CSF3R; the disease is spontaneous abortion.